|
Solid Neoplasm
|
0.030 |
AlteredExpression
|
phenotype |
BEFREE |
Whereas elevated levels of PIM1 and PIM2 were mostly found in hematologic malignancies and prostate cancer, increased PIM3 expression was observed in different solid tumors.
|
20145274 |
2010 |
|
ANOPHTHALMIA AND PULMONARY HYPOPLASIA
|
0.020 |
PosttranslationalModification
|
disease |
BEFREE |
We were able to confirm upregulation of the Pim-3 oncogene in PDAC tissues and cell lines versus normal samples.
|
23760491 |
2013 |
|
Liver carcinoma
|
0.090 |
AlteredExpression
|
disease |
BEFREE |
We previously observed that Pim-3, a member of the proto-oncogene Pim family that expresses serine/threonine kinase activity, was aberrantly expressed in human and mouse hepatomas but not in normal liver.
|
16818649 |
2006 |
|
Tumor Cell Invasion
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
We found that sh-Pim-3 inhibited B16F10 cell migration and invasion in vitro.
|
29370558 |
2018 |
|
Pancreatic carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We constructed retroviral vectors for human Pim-3 and a kinase-dead mutant of human Pim-3 (K69M); the retroviral supernatants generated from these vectors were then used to infect the human pancreatic cancer cell line MiaPaCa-2 to establish stable cell lines.
|
23845873 |
2013 |
|
Malignant neoplasm of pancreas
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We constructed retroviral vectors for human Pim-3 and a kinase-dead mutant of human Pim-3 (K69M); the retroviral supernatants generated from these vectors were then used to infect the human pancreatic cancer cell line MiaPaCa-2 to establish stable cell lines.
|
23845873 |
2013 |
|
Neoplasms
|
0.090 |
Biomarker
|
group |
BEFREE |
Using knockdown studies, we showed that PIM1 contributes to melanoma cell proliferation and tumor growth in vivo; however, the presence of PIM2 and PIM3 could also influence the outcome.
|
27448973 |
2016 |
|
Carcinogenesis
|
0.070 |
GeneticVariation
|
phenotype |
BEFREE |
To assess the role of Pim-3 in human pancreatic carcinogenesis in vivo and to determine the underlying Pim-3 signaling regulatory mechanisms, we established MiaPaca-2 cells overexpressing wild-type Pim-3 or Pim-3 kinase dead mutants (K69M-Pim-3) as well as PCI55 cells stably expressing Pim-3 shRNA or scrambled shRNA in a tetracycline-inducible manner.
|
24789328 |
2014 |
|
Malignant Neoplasms
|
0.050 |
Biomarker
|
group |
BEFREE |
Thus, Pim-3 kinase may serve as a novel molecular target for developing targeting drugs against pancreatic and other types of cancer.
|
25071334 |
2014 |
|
Primary malignant neoplasm
|
0.030 |
Biomarker
|
group |
BEFREE |
Thus, Pim-3 kinase may serve as a novel molecular target for developing targeting drugs against pancreatic and other types of cancer.
|
25071334 |
2014 |
|
Malignant Neoplasms
|
0.050 |
Biomarker
|
group |
BEFREE |
Thus, Pim-3 kinase may be a candidate molecule for the development of molecular targeting drugs against cancer.
|
21518143 |
2011 |
|
Primary malignant neoplasm
|
0.030 |
Biomarker
|
group |
BEFREE |
Thus, Pim-3 kinase may be a candidate molecule for the development of molecular targeting drugs against cancer.
|
21518143 |
2011 |
|
Pancreatic carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
These results suggest combining drug therapies that inhibit Pim kinases, such as Pim-3, with chemotherapeutic agents, to aid in decreasing chemoresistance in pancreatic cancer.
|
23760491 |
2013 |
|
Malignant neoplasm of pancreas
|
0.100 |
Biomarker
|
disease |
BEFREE |
These results suggest combining drug therapies that inhibit Pim kinases, such as Pim-3, with chemotherapeutic agents, to aid in decreasing chemoresistance in pancreatic cancer.
|
23760491 |
2013 |
|
Tuberous Sclerosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
These results demonstrate that PIM3 is induced upon mTORC1 inhibition, with potential implications for the effects of mTORC1 inhibitors in TSC, cancers, and the many other disease settings influenced by aberrant mTORC1 signaling.
|
29170467 |
2017 |
|
Colon Carcinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
These observations suggest that Pim-3 can inactivate Bad by phosphorylating its Ser(112) in human colon cancer cells and thus may prevent apoptosis and promote progression of human colon cancer.
|
17270021 |
2007 |
|
Malignant tumor of colon
|
0.010 |
Biomarker
|
disease |
BEFREE |
These observations suggest that Pim-3 can inactivate Bad by phosphorylating its Ser(112) in human colon cancer cells and thus may prevent apoptosis and promote progression of human colon cancer.
|
17270021 |
2007 |
|
Malignant Neoplasms
|
0.050 |
AlteredExpression
|
group |
BEFREE |
These observations imply that the chemical and its related compounds may be effective for the treatment of cancers in which there is aberrant Pim-3 expression.
|
21981263 |
2012 |
|
Carcinogenesis
|
0.070 |
Biomarker
|
phenotype |
BEFREE |
There is increasing evidence suggesting that the establishment of Pim-3 is involved in tumorigenesis.
|
26768612 |
2016 |
|
Neoplasm Metastasis
|
0.060 |
AlteredExpression
|
phenotype |
BEFREE |
There are significant correlations between higher Pim-3 expression levels with the FIGO stage, histopathological subtypes, and distant metastasis in ovarian cancer patients.
|
25921139 |
2015 |
|
Pancreatic carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
There are reports indicating that overexpression of PIM3 is associated with the promotion of pancreatic cancer cell proliferation.
|
26238203 |
2015 |
|
Malignant neoplasm of pancreas
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
There are reports indicating that overexpression of PIM3 is associated with the promotion of pancreatic cancer cell proliferation.
|
26238203 |
2015 |
|
Inflammatory Bowel Diseases
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Therapeutic dosing of a PIM-1/3 inhibitor was efficacious in a CD4+ T cell-mediated model of inflammatory bowel disease suggesting that PIM-1 and PIM-3 kinase activity contributes to sustained disease severity.
|
22078270 |
2012 |
|
Colorectal Carcinoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
The relationship between colorectal cancer (CRC) and cholesterol has been confirmed for many years, but the mechanism was not very clear. miR-33a was important in cholesterol metabolism and was abnormally expressed in many tumors, thus our study hypothesized that cholesterol effect on CRC by regulating miR-33a and its target gene PIM3, and verify it by series of assay.
|
30827510 |
2019 |
|
Malignant Neoplasms
|
0.050 |
Biomarker
|
group |
BEFREE |
The provirus integrating site Moloney murine leukemia virus (PIM) family of serine/threonine protein kinases is composed of three members, PIM1, PIM2 and PIM3, which have been identified as oncoproteins in various malignancies.
|
27826617 |
2016 |